Clinical Features of Graves' Disease The symptoms of hyperthyroidism are relatively non-specific, but the combination of weight loss and an increased appetite is very suggestive of thyroid overactivity. Many patients referred to an endocrinologist are found to have a primary psychiatric problem such as an anxiety state. The signs of thyrotoxicosis and Graves' Disease are shown in Figs. 17.20. See later: • Symptoms of Thyrotoxicosis • Graves Disease – Tremor • Graves Disease – Goitre • Graves Disease – Eye Signs • Graves Disease – Localised Myxoedema • Graves Disease – Acropachy • Graves Disease – Onchylosis • Graves Disease – Vitiligo • Graves Disease – Leucotrichia